Skin-Identical Skincare · One Cream, Every Night

All-in-One Night Cream

SEISUI Biomimetic Barrier Night Cream bottle

Biomimetic Barrier
Night Cream

Skin-Identical Skincare

All your skin needs. In one cream.

Serum-level actives. One cream for face, eyes and neck, in place of separate serums, eye cream and moisturiser.

A deeply restorative night cream that combines encapsulated retinal with biomimetic lipids, layered the same way as your skin’s natural barrier. It helps restore balance, strengthen the barrier and keep skin healthy over time.

It works while you sleep. Wake up to skin that feels nourished, smoother and more balanced.

Targets
Fine lines & wrinkles · Uneven texture · Dullness & uneven tone · Blemishes · Dehydration · Weakened barrier
Skin types
All, including sensitive
Your evening
Cleanse, then SEISUI on face, neck and eye area. That’s it.
€12050 ml / 1.7 fl oz

Free shipping on all orders

  1. 01

    CleanseIn the evening, cleanse your face and gently pat the skin dry.

  2. 02

    ApplyWarm a pea-sized amount between your fingertips and press it gently onto face, neck and the delicate eye area, as you would an eye cream.

  3. 03

    Build upBegin with two to three evenings a week and increase to nightly use as your skin becomes accustomed to retinal.

  4. 04

    ProtectRetinal can make skin more sensitive to the sun. Apply a broad-spectrum SPF 30 or higher the following morning.

Designed for all skin types, including sensitive skin, and especially for skin showing first signs of ageing, uneven texture or a weakened barrier.

A night cream for evening use. No added fragrance.

  • For external use only. Avoid contact with the eyes; if contact occurs, rinse thoroughly with water.
  • Do not apply to broken or irritated skin.
  • Mild tingling, dryness or flaking can occur when you first use a retinoid. If it does, use SEISUI less often until your skin adjusts.
  • Use a broad-spectrum sunscreen during the day and limit direct sun exposure.
  • Not recommended during pregnancy or breastfeeding.
  • Store at room temperature, away from direct sunlight. The airless pump protects retinal from light and air.

Behind the Formula

Key Ingredients.
Working as One.

  • Encapsulated Retinal

    Renews and smooths

  • Lipid-Soluble Vitamin C

    Brightens and protects

  • Palmitoyl Pentapeptide-4

    Refines lines and texture

  • Niacinamide

    Evens and balances

  • Five Ceramides

    Strengthen the barrier

  • Phospholipid Membrane

    Skin-identical structure

  • Cholesterol + Phytosphingosine

    Complete the barrier lipids

  • Ectoin

    Protects and hydrates

  • Vitamin E, EGCG + Rosemary

    Antioxidant protection

SEISUI Biomimetic Barrier Cream surrounded by the names of its key ingredients

Customer Study

Felt by Our Customers.
Seen on Their Skin.

98%

Agree that their skin feels instantly and deeply hydrated.

82%

Agree that their skin tone improved.

95%

Agree that the cream smoothed the appearance of fine lines and wrinkles.

Results from a consumer-perception study. Based on participants' self-assessments. 3-week study, 21 focus trial responses.

Eye area before using SEISUI
Before
Eye area after using SEISUI
After
Nasolabial fold before using SEISUI
Before
Nasolabial fold after using SEISUI
After
Forehead before using SEISUI
Before
Forehead after using SEISUI
After
Forehead before using SEISUI
Before
Forehead after using SEISUI
After

01 / 04 · Eye area

Untouched photos: no retouching or filters. Taken before and after 3 weeks of use.

Macro of a variegated green leaf edge beaded with fine water droplets

The Difference

Most Creams Coat the Skin.
SEISUI Is Made Like Skin.

Conventional night cream

SEISUI

Oil-and-water emulsion that sits on the skin

Phospholipid membrane structure modelled on the skin barrier

One ceramide, often in trace amounts

Five ceramides with cholesterol and phytosphingosine

Retinoid that can stress the barrier

Encapsulated retinal surrounded by barrier support

Serum, eye cream and moisturiser bought separately

One evening step for face, eyes and neck

All-in-One

Your Entire Evening Routine.
One Step.

Serum-level actives. The comfort of a cream.

Instead of

  • Retinal serum
  • Vitamin C serum
  • Peptide serum
  • Eye cream
  • Barrier repair cream
  • Night moisturiser

Your routine

Evening

Cleanse  →  SEISUI

On face, neck and the delicate eye area.

Morning

Your usual routine

Always finished with a broad-spectrum sunscreen.

Fewer products. Less guesswork. Everything your skin needs, working together.

Ingredients

What's Inside
Matters.

Every ingredient in SEISUI has a job. The membrane and skin-identical lipids build the base; retinal, vitamin C and a peptide do the renewing. All in one night cream.

Active Ingredients

Retinal represented through champagne-toned molecular and membrane science art

01

Retinal

Encapsulated vitamin A for visible renewal, improving the look of wrinkles, texture, firmness and radiance. Reported to act up to 11× faster than standard retinol.

Ascorbyl Tetraisopalmitate represented through champagne-toned molecular and membrane science art

02

Ascorbyl Tetraisopalmitate

An oil-soluble form of vitamin C that gives antioxidant protection and helps skin look brighter and more even.

Palmitoyl Pentapeptide-4 represented through champagne-toned molecular and membrane science art

03

Palmitoyl Pentapeptide-4

An anti-ageing peptide that helps skin look smoother and softens the look of wrinkles.

Ceramides represented through champagne-toned molecular and membrane science art

04

Ceramides

Five ceramides (NP, AP, AS, NG and EOP) work together with cholesterol and phytosphingosine to support the skin barrier and help maintain moisture.

Phosphatidylcholine + Hydrogenated Phosphatidylcholine represented through champagne-toned molecular and membrane science art

05

Phosphatidylcholine + Hydrogenated Phosphatidylcholine

The base of SEISUI’s membrane. These lipids form thin, stacked layers like those in your skin.

Cholesterol + Phytosphingosine represented through champagne-toned molecular and membrane science art

06

Cholesterol + Phytosphingosine

Important components of the skin’s barrier lipid system that work alongside the ceramides to support barrier function and resilience.

Niacinamide represented through champagne-toned molecular and membrane science art

07

Niacinamide

Vitamin B3 that supports barrier function, hydration and a more even-looking complexion.

Ectoin represented through champagne-toned molecular and membrane science art

08

Ectoin

A protective molecule that keeps skin hydrated and helps it cope with stress from the environment.

Vitamin E represented through champagne-toned molecular and membrane science art

09

Vitamin E

A lipid-soluble antioxidant that helps protect skin lipids from oxidative stress.

EGCG + Rosemary Extract represented through champagne-toned molecular and membrane science art

10

EGCG + Rosemary Extract

Antioxidant ingredients that provide additional protection against oxidative stress.

Swipe to explore

Aqua, Hydrogenated Phosphatidylcholine, Glycerin, Dimethyl Isosorbide, Simmondsia Chinensis Seed Oil, Vitis Vinifera Seed Oil, Caprylic/Capric Triglyceride, Pentylene Glycol, Butyrospermum Parkii Butter, Cetearyl Olivate, Panthenol, Tocopherol, Sodium Lactate, Sodium PCA, Sodium Levulinate, Alpha-Glucan Oligosaccharide, Rhus Verniciflua Peel Cera, 2,3-Butanediol, Ascorbyl Tetraisopalmitate, Sorbitan Olivate, Sodium Polyphosphate, Sodium Anisate, Ectoin, Ceramide NP, 1,2-Heptanediol, Helianthus Annuus Seed Oil, Hydrogenated Lecithin, Retinal, Glyceryl Citrate/Lactate/Linoleate/Oleate, Phosphatidylcholine, Mannitol, Glyceryl Stearate, Tocopheryl Linoleate/Oleate, Phytosphingosine, Polyglyceryl-10 Laurate, Glycine, Inositol, Lactic Acid, Niacinamide, Urea, Ethyl Oleate, Rosmarinus Officinalis Leaf Extract, Epigallocatechin Gallate, Cetyl Alcohol, Ceramide AP, Ceramide AS, Ceramide NG, Cholesterol, Palmitoyl Pentapeptide-4, Citric Acid, Camphor*, Ceramide EOP, Pinene*.

*Naturally occurring constituents of our natural active ingredients.

No added fragrance.

Formulated without parabens, sulfates, mineral oils/petrolatum/paraffin, silicones, talc or DEA.

High-quality ingredients selected for their functional role in the formula.

No fillers. Only what the formula needs.

The Science of Renewal

The Result Is Skin That Feels
Stronger, More Balanced
and Visibly More Vibrant

Retinal, vitamins and plant-based ingredients work together to improve skin texture, support firmness and keep your complexion calm and healthy.

Half-face portrait of a woman with natural, unretouched skin against a soft grey background

Results

What You Will Experience

A swipe of SEISUI's pale-yellow retinal night cream showing its rich, glossy texture

The textureSmooth and silky, it glides on easily and absorbs without heaviness, leaving skin soft and comfortable.

Smoother, More Refined Skin

Encapsulated retinal works overnight to gently renew the skin, so it looks smoother and more refined over time.

Long-Lasting Hydration

The biomimetic lipid structure helps the skin hold on to moisture, for hydration that lasts through the day.

Stronger Skin Barrier

Ceramides and phospholipids help repair and strengthen your skin's natural barrier over time.

Balanced, Calm Complexion

Gentle, skin-friendly ingredients and no added fragrance help keep skin calm and balanced.

Questions

Frequently Asked

In the evening, as the final step of your routine. Retinal works best overnight, while the skin-identical lipids support the barrier as you sleep.

SEISUI surrounds encapsulated retinal with ceramides, cholesterol, phytosphingosine and ectoin to make the experience as gentle as possible. If your skin is sensitive or new to retinoids, introduce it gradually and try it on a small area first.

SEISUI is designed to be your complete evening step. Avoid using other retinoids or strong exfoliating acids alongside it. In the morning, follow your usual routine and finish with a broad-spectrum sunscreen.

No. SEISUI brings retinal, vitamin C, peptide technology, ceramides and skin-identical lipids together in one formula, so it takes the place of separate serums, eye cream and night moisturiser. Simply cleanse and apply SEISUI.

Yes. SEISUI is gentle enough to use around the eye area as you would an eye cream. Pat a small amount along the orbital bone and avoid direct contact with the eyes.

Skin often feels more comfortable and hydrated soon after you start. The renewing effects of retinal build gradually; the clinical studies on retinaldehyde described on this site measured improvements after three months of regular use.

We do not recommend using retinoid products during pregnancy or breastfeeding. Please speak to your doctor if you are unsure.

No fragrance is added. Camphor and pinene appear in the ingredient list only as naturally occurring constituents of the formula's natural active ingredients such as rosemary extract.

A woman gently pressing a soft white towel to her face after cleansing

Your Evening Ritual
Awaits

Apply in the evening. Breathe. Be present.
Let this be your sacred moment.

Be one with your skin.